Expanding the Y Dwarf Census with Spitzer Follow-up of the Coldest CatWISE Solar Neighborhood Discoveries

We present Spitzer 3.6 and 4.5 μm follow-up of 170 candidate extremely cool brown dwarfs newly discovered via the combination of Wide-field Infrared Survey Explorer (WISE) and NEOWISE imaging at 3–5 μm. CatWISE, a joint analysis of archival WISE and NEOWISE data, has improved upon the motion measurements of AllWISE by leveraging a >10× time baseline enhancement, from 0.5 yr (AllWISE) to 6.5 yr (CatWISE). As a result, CatWISE motion selection has yielded a large sample of previously unrecognized brown dwarf candidates, many of which have archival detections exclusively in the WISE 4.6 μm (W2) channel, suggesting that they could be both exceptionally cold and nearby. Where these objects go undetected in WISE W1 (3.4 μm), Spitzer can provide critically informative detections at 3.6 μm. Of our motion-confirmed discoveries, 17 have a best-fit Spitzer [3.6]–[4.5] color most consistent with spectral type Y. It is likely that CWISEP J144606.62–231717.8 (μ ≈ 1.”3 yr⁻¹) is the reddest, and therefore potentially coldest, member of our sample with a very uncertain [3.6]–[4.5] color of 3.71 ± 0.44 mag. We also highlight our highest proper-motion discovery, WISEA J153429.75–104303.3, with μ ≈ 2.”7 yr⁻¹. Given that the prior list of confirmed and presumed Y dwarfs consists of just 27 objects, the Spitzer follow-up presented in this work has substantially expanded the sample of identified Y dwarfs. Our new discoveries thus represent significant progress toward understanding the bottom of the substellar mass function, investigating the diversity of the Y dwarf population, and selecting optimal brown dwarf targets for James Webb Space Telescope spectroscopy

Evaluation of antimicrobial effectiveness of pimaricin-loaded thermosensitive nanohydrogels in grape juice

Pimaricin-loaded poly(N-isopropylacrylamide) nanohydrogels with and without acrylic acid, were evaluated as food-spoilage inhibitors in a model system and a real food product: grape juice. Pimaricin was proposed as a non-allergenic alternative to sulphites for protecting juices against recontamination. However, pimaricin may degrade under conditions and treatments (heating, acidification, lighting) commonly applied in producing fresh juices. Nanohydrogel encapsulation may be a feasible procedure to avoid pimaricin degradation, improving its antimicrobial activity. Pimaricin-free nanohydrogels did not affect the growth of the indicator yeast either in the food model system or in grape juice. Conversely, pimaricin-loaded nanohydrogels effectively inhibited the growth of the indicator yeast. In some cases, the inhibition was extended even further than using free pimaricin. For instance, in the food model system, pimaricin-loaded nanohydrogels with acrylic acid (NPPNIPA-20AA(5)) prevented the yeast growth for more than 81 h while free pimaricin was only effective for 12 h. Despite pimaricin-loaded nanohydrogels without acrylic acid (NPPNIPA(5)) were able to reduce maximum yeast growth, as in all treatments with pimaricin, the extent of the inhibitory effect was not significantly (p>0.05) different to that achieved with free pimaricin. In grape juice, both free pimaricin and NPPNIPA-20AA(5) treatment completely inhibited the growth of the indicator yeast until the end of the bioassay. However, the latter provided similar inhibition levels using a smaller amount of pimaricin due to PNIPA-20AA(5) protection and its controlled release from the nanohydrogel. Therefore, nanohydrogel encapsulation may help to optimise antifungal treatments and decrease the incidence of food allergies.Funded by grant (MAT 2006-11662-CO3-CO2-C01/MAT 2010-21509-C03-01/EUI 2008-00115) from the “Ministerio de Educación y Ciencia” (Spain). Grant (SFRH/BPD/87910/2012) from the Fundação para a Ciência e Tecnologia (FCT, Portugal). Marie Curie COFUND Postdoctoral Research Fellow

The CatWISE Preliminary Catalog: Motions from WISE and NEOWISE Data

CatWISE is a program to catalog sources selected from combined WISE and NEOWISE all-sky survey data at 3.4 and 4.6 μm (W1 and W2). The CatWISE Preliminary Catalog consists of 900,849,014 sources measured in data collected from 2010 to 2016. This data set represents four times as many exposures and spans over 10 times as large a time baseline as that used for the AllWISE Catalog. CatWISE adapts AllWISE software to measure the sources in coadded images created from six-month subsets of these data, each representing one coverage of the inertial sky, or epoch. The catalog includes the measured motion of sources in eight epochs over the 6.5 yr span of the data. From comparison to Spitzer, signal-to-noise ratio = 5 limits in magnitudes in the Vega system are W1 = 17.67 and W2 = 16.47, compared to W1 = 16.96 and W2 = 16.02 for AllWISE. From comparison to Gaia, CatWISE positions have typical accuracies of 50 mas for stars at W1 = 10 mag and 275 mas for stars at W1 = 15.5 mag. Proper motions have typical accuracies of 10 mas yr⁻¹ and 30 mas yr⁻¹ for stars with these brightnesses, an order of magnitude better than from AllWISE. The catalog is available in the WISE/NEOWISE Enhanced and Contributed Products area of the NASA/IPAC Infrared Science Archive

The Next Linear Collider Test Accelerator

During the past several years, there has been tremendous progress on the development of the RF system and accelerating structures for a Next Linear Collider (NLC). Developments include high-power klystrons, RF pulse compression systems and damped/detuned accelerator structures to reduce wakefields. In order to integrate these separate development efforts into an actual X-band accelerator capable of accelerating the electron beams necessary for an NLC, we are building an NLC Test Accelerator (NLCTA). The goal of the NLCTA is to bring together all elements of the entire accelerating system by constructing and reliably operating an engineered model of a high-gradient linac suitable for the NLC. The NLCTA will serve as a testbed as the design of the NLC evolves. In addition to testing the RF acceleration system, the NLCTA is designed to address many questions related to the dynamics of the beam during acceleration. In this paper, we will report on the status of the design, component development, and construction of the NLC Test Accelerator

The CatWISE2020 Catalog

The CatWISE2020 Catalog consists of 1,890,715,640 sources over the entire sky selected from WISE and NEOWISE survey data at 3.4 and 4.6 $\mu$m (W1 and W2) collected from 2010 Jan. 7 to 2018 Dec. 13. This dataset adds two years to that used for the CatWISE Preliminary Catalog (Eisenhardt et al., 2020), bringing the total to six times as many exposures spanning over sixteen times as large a time baseline as the AllWISE catalog. The other major change from the CatWISE Preliminary Catalog is that the detection list for the CatWISE2020 Catalog was generated using ${\it crowdsource}$ (Schlafly et al. 2019), while the CatWISE Preliminary Catalog used the detection software used for AllWISE. These two factors result in roughly twice as many sources in the CatWISE2020 Catalog. The scatter with respect to ${\it Spitzer}$ photometry at faint magnitudes in the COSMOS field, which is out of the Galactic plane and at low ecliptic latitude (corresponding to lower WISE coverage depth) is similar to that for the CatWISE Preliminary Catalog. The 90% completeness depth for the CatWISE2020 Catalog is at W1=17.7 mag and W2=17.5 mag, 1.7 mag deeper than in the CatWISE Preliminary Catalog. From comparison to ${\it Gaia}$, CatWISE2020 motions are accurate at the 20 mas yr$^{-1}$ level for W1$\sim$15 mag sources, and at the $\sim100$ mas yr$^{-1}$ level for W1$\sim$17 mag sources. This level of precision represents a 12$\times$ improvement over AllWISE. The CatWISE catalogs are available in the WISE/NEOWISE Enhanced and Contributed Products area of the NASA/IPAC Infrared Science Archive.Comment: 27 pages, 24 figure, 2 tables. Accepted for publication in ApJS. arXiv admin note: text overlap with arXiv:1908.0890

Novel Fusion of MYST/Esa1-Associated Factor 6 and PHF1 in Endometrial Stromal Sarcoma

Rearrangement of chromosome band 6p21 is recurrent in endometrial stromal sarcoma (ESS) and targets the PHF1 gene. So far, PHF1 was found to be the 3′ partner in the JAZF1-PHF1 and EPC1-PHF1 chimeras but since the 6p21 rearrangements involve also other chromosomal translocation partners, other PHF1-fusions seem likely. Here, we show that PHF1 is recombined with a novel fusion partner, MEAF6 from 1p34, in an ESS carrying a t(1;6)(p34;p21) translocation as the sole karyotypic anomaly. 5′-RACE, RT-PCR, and sequencing showed the presence of an MEAF6-PHF1 chimera in the tumor with exon 5 of MEAF6 being fused in-frame to exon 2 of PHF1 so that the entire PHF1 coding region becomes the 3′ terminal part of the MEAF6-PHF1 fusion. The predicted fusion protein is composed of 750 amino acids and contains the histone acetyltransferase subunit NuA4 domain of MEAF6 and the tudor, PHD zinc finger, and MTF2 domains of PHF1. Although the specific functions of the MEAF6 and PHF1 proteins and why they are targeted by a neoplasia-specific gene fusion are not directly apparent, it seems that rearrangement of genes involved in acetylation (EPC1, MEAF6) and methylation (PHF1), resulting in aberrant gene expression, is a common theme in ESS pathogenesis

Combination of scoring schemes for protein docking

<p>Abstract</p> <p>Background</p> <p>Docking algorithms are developed to predict in which orientation two proteins are likely to bind under natural conditions. The currently used methods usually consist of a sampling step followed by a scoring step. We developed a weighted geometric correlation based on optimised atom specific weighting factors and combined them with our previously published amino acid specific scoring and with a comprehensive SVM-based scoring function.</p> <p>Results</p> <p>The scoring with the atom specific weighting factors yields better results than the amino acid specific scoring. In combination with SVM-based scoring functions the percentage of complexes for which a near native structure can be predicted within the top 100 ranks increased from 14% with the geometric scoring to 54% with the combination of all scoring functions. Especially for the enzyme-inhibitor complexes the results of the ranking are excellent. For half of these complexes a near-native structure can be predicted within the first 10 proposed structures and for more than 86% of all enzyme-inhibitor complexes within the first 50 predicted structures.</p> <p>Conclusion</p> <p>We were able to develop a combination of different scoring schemes which considers a series of previously described and some new scoring criteria yielding a remarkable improvement of prediction quality.</p